Oral Presentation- Symposium 12th International Mammalogical Congress

Body water conservation through selective brain cooling by the carotid rete: A physiological feature for surviving climate change? (#351)

W. Maartin Strauss 1 2 , Robyn S Hetem 2 3 , Duncan Mitchelll 2 4 , Shane K Maloney 2 4 , Haley D O'Brien 5 , Leith CR Meyer 2 6 , Andrea Fuller 2 6
  1. University of South Africa / Wits University, Johannesburg, Gauteng, South Africa
  2. Brain Function Research Group, School of Physiology, Faculty of Heath Sciences, Wits University, Johannesburg, Gauteng, South Africa
  3. School of Animal, Plant and Environmental Sciences, Faculty of Science, Wits University, Johannesburg, Gauteng, South Africa
  4. School of Anatomy, Physiology, and Human Biology, University of Western Australia, Perth, Western Australia, Australia
  5. Department of Anatomy and Cell Biology , Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma, USA
  6. Department of Paraclinical Science, Pharmacology Faculty of Veterinary Sciences, Onderstepoort, University of Pretoria, Pretoria, Gauteng, South Africa

Some mammals have the ability to lower their hypothalamic temperature below that of carotid arterial blood temperature, a process termed selective brain cooling. Although the requisite anatomical structure that facilitates this physiological process, the carotid rete, is present in members of the Cetartiodactyla, Felidae and Canidae, the carotid rete is particularly well developed in the artiodactyls, e.g. antelopes, cattle, sheep and goats. First described in the domestic cat, the seemingly obvious function initially attributed to selective brain cooling was that of protecting the brain from thermal damage. However, hyperthermia is not a prerequisite for selective brain cooling, and selective brain cooling can be exhibited at all times of the day, even when carotid arterial blood temperature is relatively low. More recently, it has been shown that selective brain cooling functions primarily as a water-conservation mechanism, allowing artiodactyls to save more than half of their daily water requirements. Here, we argue that the evolutionary success of the artiodactyls may, in part, be attributed to the evolution of the carotid rete and the resulting ability to conserve body water during past environmental conditions, and we suggest that this group of mammals may therefore have a selective advantage in the hotter and drier conditions associated with current anthropogenic climate change. A better understanding of how selective brain cooling provides physiological plasticity to mammals in changing environments will improve our ability to predict their responses and to implement appropriate conservation measures.